MovDisordV3, Main, Exploration, bibRecord, 002B87

Self‐reported adherence versus pill count in Parkinson's disease: The NET‐PD experience

Identifieur interne : 002B87 ( Main/Exploration ); précédent : 002B86; suivant : 002B88

Self‐reported adherence versus pill count in Parkinson's disease: The NET‐PD experience

Auteurs : Jordan J. Elm [États-Unis] ; Cornelia Kamp [États-Unis] ; Barbara C. Tilley [États-Unis] ; Paulo Guimaraes [États-Unis] ; Debbie Fraser [États-Unis] ; Patricia Deppen [États-Unis] ; Alicia Brocht [États-Unis] ; Chris Weaver [États-Unis] ; Susan Bennett [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-04-30.

RBID : ISTEX:E4796225A5AE3C63A0A32A25E8F44AD5BA9E7227

Descripteurs français

Pascal (Inist)
- Essai clinique, Etude comparative, Expérience, Parkinson maladie, Système nerveux pathologie, Traitement.

English descriptors

KwdEn :
- Antiparkinson Agents (therapeutic use), Clinical trial, Comparative study, Experience, Humans, Middle Aged, Morisky score, Nervous system diseases, Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Patient Compliance, Predictive Value of Tests, Questionnaires, Reproducibility of Results, Treatment, clinical trial, treatment adherence.
MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- drug therapy : Parkinson Disease.
- Humans, Middle Aged, Patient Compliance, Predictive Value of Tests, Questionnaires, Reproducibility of Results.

Abstract

Purpose: To compare the Morisky medication adherence questionnaire to pill counts as measures of adherence in the NET‐PD futility clinical trials. Background: Like in other chronic diseases, non‐adherence with medications occurs in Parkinson's disease (PD), although nonadherence has not been of significant concern in most PD clinical trials. The most common approach to assessment is to do a pill count at each visit. The simple, 4‐question Morisky medication adherence questionnaire may provide an alternative approach to monitoring treatment adherence in PD. Methods: Adherence data from two NET‐PD Phase II clinical trials enrolling a total of 413 participants were analyzed. The association between demographic and clinical characteristics and adherence was explored. Results: Ninety‐percent of participants took 80% or more of the study drug. However, the Morisky medication adherence questionnaires showed 56% report high and 44% report medium adherence. Agreement between the two measures is fair (ICC = 0.40). Conclusions: Overall adherence as assessed by pill count appears high. The Morisky medication adherence questionnaire may be useful in PD clinical trials, since it is moderately correlated to pill count and may be more sensitive to nonadherence. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/E4796225A5AE3C63A0A32A25E8F44AD5BA9E7227/fulltext/pdf

DOI: 10.1002/mds.21409

Affiliations:

Le document en format XML

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<author><name sortKey="Kamp, Cornelia" sort="Kamp, Cornelia" uniqKey="Kamp C" first="Cornelia" last="Kamp">Cornelia Kamp</name>
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<author><name sortKey="Tilley, Barbara C" sort="Tilley, Barbara C" uniqKey="Tilley B" first="Barbara C." last="Tilley">Barbara C. Tilley</name>
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<front><div type="abstract" xml:lang="en">Purpose: To compare the Morisky medication adherence questionnaire to pill counts as measures of adherence in the NET‐PD futility clinical trials. Background: Like in other chronic diseases, non‐adherence with medications occurs in Parkinson's disease (PD), although nonadherence has not been of significant concern in most PD clinical trials. The most common approach to assessment is to do a pill count at each visit. The simple, 4‐question Morisky medication adherence questionnaire may provide an alternative approach to monitoring treatment adherence in PD. Methods: Adherence data from two NET‐PD Phase II clinical trials enrolling a total of 413 participants were analyzed. The association between demographic and clinical characteristics and adherence was explored. Results: Ninety‐percent of participants took 80% or more of the study drug. However, the Morisky medication adherence questionnaires showed 56% report high and 44% report medium adherence. Agreement between the two measures is fair (ICC = 0.40). Conclusions: Overall adherence as assessed by pill count appears high. The Morisky medication adherence questionnaire may be useful in PD clinical trials, since it is moderately correlated to pill count and may be more sensitive to nonadherence. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

Self‐reported adherence versus pill count in Parkinson's disease: The NET‐PD experience

Self‐reported adherence versus pill count in Parkinson's disease: The NET‐PD experience

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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